association of methylenetetrahydrofolate reductase (mthfr) gene c677t and a1298c polymorphisms with myocardial infarction from north of fars province

background: the association between methylene tetrahydrofolate reductase polymorphism and coronary artery diseases risk has been both confirmed and refuted in a number of published studies. the aim of this study was to investigate whether genetic polymorphisms of mthfr (c677t, a1298c) contributed to the development of myocardial infarction (mi). materials and methods: the present case-control study consisted of 54 patients with a history of mi and 54 gender-matched normal controls. the snps genotypes were determined using polymerase chain reaction followed by restriction fragment length polymorphism method. results: no significant association of the mthfr a1298c with the risk of mi was observed. however, the allele frequencies of c677t snp differed significantly among patients and controls (0.83 vs. 0.30). a strong positive relationship between the tt genotype and the risk of mi supported with a significant p-value < 0.001 (or= 11.87, 95% ci: 4.7- 29.9, p < 0.001). conclusions: the results of the present study show the importance of c677t snp as a potential biomarker for screening susceptible cases to mi.